Ace The SPEX Exam

Be prepared for the Federation of State Medical Boards® with 6,365 Questions that our experts have selected to simulate the real exam.

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About the Question Bank

Our review is designed to help you maximize your score on the SPEX Exam. StatPearls questions and articles are based on our experts review of the Federation of State Medical Boards® topics. Each review course is designed to empower you to assess your knowledge and understanding of medical principles and concepts found on the SPEX Exam.

Multiple-choice questions

We have 6,365 Multiple-choice 1st, 2nd, and 3rd order questions with four detailed teaching points linked to 3,559 PubMed indexed review articles related to the SPEX Examination. You can customize practice questions to anatomical and clinical SPEX Student subject areas. In addition, you will have access to a pre- and post-test SPEX Exam to help you target learning and identify areas that need further study. Analytics and reports allow you to compare your scores to other students.

Achieve top scores

The StatPearls SPEX prep questions, SPEX review questions, and SPEX test questions will help you achieve a top score on the SPEX Examination. 2,903 authors and 43 editors have contributed to the development of the SPEX Exam content, which is continuously refined and updated to improve your learning experience.

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SPEX Exam Overview

  • How many hours is the SPEX Exam?

    The SPEX Exam is 6 hours.

  • How many questions is the SPEX Exam?

  • What topics are covered on the SPEX Exam?

SPEX Exam MCQs (6,365)

Our question bank for the SPEX Exam covers four Cognitive Difficulty Levels:

Level 1

33 Questions

Level 2

612 Questions

Level 3

4,566 Questions

Level 4

1,154 Questions

  • Allergy and Immunology - 325 questions
  • Cardiovascular - 1569 questions
  • Connective Tissue - 194 questions
  • Ears Nose and Throat - 323 questions
  • Endocrine and Metabolic - 804 questions
  • Eyes - 262 questions
  • Gastrointestinal - 1261 questions
  • Genetics - 199 questions
  • Genitourinary - 350 questions
  • Growth and Development - 257 questions
  • Gynecologic - 263 questions
  • Hematologic - 520 questions
  • Infectious - 1636 questions
  • Integument - 601 questions
  • Musculoskeletal - 995 questions
  • Nervous - 1399 questions
  • Nutrition - 182 questions
  • Obstetric - 251 questions
  • Oncologic - 630 questions
  • Psychiatric Mental Health - 489 questions
  • Pulmonary - 940 questions
  • Renal - 435 questions
  • Surgery - 601 questions
  • Toxicology - 492 questions
  • Trauma, Injury, Safety, and Violence - 681 questions
  • Teeth/Oral - 33 questions
  • Reproductive - 47 questions
  • Sexuality and Gender - 20 questions
  • Psychiatric Addiction - 63 questions
  • Pharmacology - 576 questions
  • Thoracic - 112 questions
  • Anatomy - 113 questions
  • Behavioral - 72 questions
  • Histology - 10 questions
  • Neuroanatomy - 104 questions
  • Pathology - 201 questions
  • Biochemistry - 11 questions
  • Physiology - 211 questions
  • Embryology - 9 questions
  • Cell Biology - 7 questions
  • Manage Care and Comply Regulations - 150 questions
  • Promote Safety and Minimize Infection - 147 questions
  • Health Promotion & Maintenance (Prevent Problems) - 396 questions
  • Basic Care and Comfort (Assist Daily Living Tasks) - 47 questions
  • Pharm/Parenteral Therapy (Drugs/Vital Signs) - 1186 questions
  • Reduction Risk (Post Procedure) - 104 questions
  • Physiological Adaptation (Care Ill Patients) - 4607 questions
  • Psychosocial (Mental Health Patient/Family) - 336 questions
  • Professional Practice - 137 questions
  • Process (Analysis, Assess, Eval, Implement, Plan) - 5747 questions
  • Caring (Hope and Support) - 47 questions
  • Communication/Documentation (Oral, Written, EMR) - 56 questions
  • Teaching/Learning (Promotes Behavior Change) - 67 questions
  • Culture/Spiritualilty (Beliefs, Practices, Ethics) - 20 questions
  • Causes - 3596 questions
  • Classification - 554 questions
  • Differential - 3549 questions
  • Epidemiology - 216 questions
  • Evaluation Diagnostic Tests - 1891 questions
  • Evaluation Lab - 2130 questions
  • Evaluation Monitoring - 557 questions
  • Evaluation Nuclear Medicine - 20 questions
  • Evaluation Procedures - 1179 questions
  • Evaluation Radiologic - 1813 questions
  • Health Maint Prevention Public Health - 267 questions
  • History Physical - 7346 questions
  • Legal - 53 questions
  • Pathophysiology - 3691 questions
  • Patient Education - 431 questions
  • Prognosis Complications - 3697 questions
  • Toxicology - 370 questions
  • Treatment Medical - 3536 questions
  • Treatment Occupation/Physical Therapy - 66 questions
  • Treatment Prehospital/EMS/Disaster - 57 questions
  • Treatment Radiation - 26 questions
  • Treatment Rehabilitation - 37 questions
  • Treatment Surgical - 740 questions
  • Healthcare Ethics - 65 questions
  • Clinical Education - 95 questions
  • Environmental - 15 questions
  • Palliative - 25 questions
  • Treatment Manipulative - 7 questions
  • Airway Management - 32 questions
  • Pain Management - 71 questions
  • Sedation and Analgesic Management - 15 questions
  • Organ and Tissue Donation - 2 questions
  • Ventilatory Management - 18 questions
  • Biostatistics - 5 questions
  • Research and Evidence-Based Medicine - 50 questions
  • Resource Utilization - 12 questions
  • Vulnerable Populations - 69 questions
  • Therapeutics (Drug treatment) - 1621 questions
  • Biostatics and Calculations - 12 questions
  • Drug Information - 1069 questions
  • Pharmaceutics (Safely dosing medications) - 458 questions
  • Pharmacokinetics (Drug movement in body) - 208 questions

SPEX Exam Articles (3,559)

We link each review question to its peer-reviewed, PubMed-indexed article from StatPearls authors and editors.
We make it easy for you to reinforce topic areas you excel at and fill knowledge gaps with source material.