Tumor Lysis Syndrome

Overview

4.8 out of 5 (69 Reviews)

Credits

1.50

Pharmacology Credits

0.5

Post Assessment Questions

10

Start Date

1 Sep 2023

Last Review Date

5 Oct 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


 
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Activity Description

Tumor lysis syndrome is a critical medical condition that arises from the rapid breakdown of tumor cells, leading to significant metabolic disturbances such as hyperkalemia, hyperphosphatemia, hypocalcemia, and hyperuricemia. These disturbances can result in severe complications, including acute kidney injury, cardiac arrhythmias, and even death. Tumor lysis syndrome is commonly observed in patients undergoing treatment for hematologic malignancies such as non-Hodgkin lymphomas, acute leukemias, and Burkitt lymphoma, particularly following the initiation of chemotherapy. However, tumor lysis syndrome may also occur spontaneously.

Patients at high risk of developing tumor lysis syndrome typically have neoplasms with a high proliferative rate and significant sensitivity to chemotherapy. Prevention and early intervention are crucial. Strategies include aggressive hydration; the use of hypouricemic agents, such as allopurinol or rasburicase; and close monitoring of metabolic parameters. Timely recognition and management of tumor lysis syndrome are essential to reducing patient morbidity, emphasizing the importance of vigilant monitoring during cancer treatment. This activity reviews the epidemiology, pathophysiology, identification, evaluation, and management of tumor lysis syndrome, highlighting the role of the interprofessional team in improving outcomes for patients with this life-threatening disease condition.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify patients at risk for developing tumor lysis syndrome based on their clinical history.

  • Select interventions for patients with tumor lysis syndrome to prevent or mitigate end-organ injury and failure.

  • Apply best practices to reduce the incidence of tumor lysis syndrome in high-risk patients.

  • Implement interprofessional team strategies to improve care coordination and outcomes in patients with tumor lysis syndrome.

  • Outline the pharmacologic therapy as it applies to Tumor Lysis Syndrome

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Nurse Practitioners: StatPearls designates this activity for 1.50 ANCC contact hour(s), which includes 0.5 hour(s) of pharmacology. NPs should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Sara C. on 3/31/2021

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